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Delta-8 動物胃腸道體內(nèi)中藥物的溶解度的測定——結(jié)論、工具書類!
來源:上海謂載 瀏覽 1567 次 發(fā)布時間:2021-11-26
結(jié)論
胃腸道pH值和緩沖容量的種間差異是重要的考慮因素,尤其是對胃腸道給藥的pHresponsive配方和可電離藥物。 因此,兔子和豬的空腸、回腸和近端結(jié)腸具有相對較高的緩沖容量,而豬遠端結(jié)腸具有較低的緩沖容量是非常重要的考慮因素。 與人相比,大鼠、兔和豬的近端小腸和升結(jié)腸的液體的滲透壓和表面張力也較高。 胃腸道特征的這些差異導(dǎo)致潑尼松龍在大鼠體內(nèi)的溶解度較高(近端結(jié)腸除外),而潑尼松龍在豬和兔體內(nèi)的溶解度與人類相當(dāng)。 因此,如果在大鼠的體液中測量,中性化合物潑尼松龍的溶解度可能被高估。 另一方面,可電離藥物美沙拉秦在兔和豬體內(nèi)的溶解度在小腸中部高于人,在結(jié)腸中低于人,僅在小腸遠端與人相當(dāng)。 胃腸道環(huán)境的差異,如pH值、緩沖容量、滲透壓和表面張力,導(dǎo)致藥物溶解度的差異。 在兔子和豬中,美沙拉秦的溶解度在沿胃腸道向下移動時發(fā)生顯著變化,這在很大程度上受管腔液的pH值和滲透壓的影響。
工具書類
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Delta-8 動物胃腸道體內(nèi)中藥物的溶解度的測定——摘要、介紹
Delta-8 動物胃腸道體內(nèi)中藥物的溶解度的測定——材料和方法